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NCT03290950: Phase 2 - A Study of Daratumumab in Patients With NDMM wKRd-D - Manhattan Trial

Updated: Feb 21

  • MANHATTAN TRIAL

  • NCT03290950: Phase 2 - A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma

  • Dara-KRd


Manhattan Trial

A Study of Daratumumab in Patients With Newly Diagnosed Multiple Myeloma


This is a study to test the safety and effectiveness of the study drug, daratumumab in combination with carfilzomib, lenalidomide and dexamethasone. The purpose of this study is to test whether giving daratumumab along with the other drugs (carfilzomib, lenalidomide and dexamethasone) is safe for patients.


Carfilzomib (Kyprolis)

Lenalidomide (Revlimid)

Dexamethasone (Decadron)

Daratumumab (Darzalex)


Sponsor


Collaborator

 

ClinicalTrials.gov Identifier: NCT03290950

Official Title: Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Newly-Diagnosed Multiple Myeloma: A Clinical and Correlative Phase II Study

First Posted : September 25, 2017

 




 

653.Myeloma: Therapy, excluding Transplantation| November 13, 2019

Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy Provides Unprecedented MRD Negativity Rates in Newly Diagnosed Multiple Myeloma: A Clinical and Correlative Phase 2 Study

 

Monday, December 7, 2020, 7:00 AM-3:30 PM

3204 Weekly Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab (wKRd-D) Combination Therapy in Newly Diagnosed Multiple Myeloma: Final Results from a Clinical and Correlative Phase 2 Study

Program: Oral and Poster Abstracts

Session: 653. Myeloma/Amyloidosis: Therapy, excluding Transplantation: Poster III

Hematology Disease Topics & Pathways:

multiple myeloma, Adult, Diseases, Therapies, Combinations, Elderly, Young Adult, Plasma Cell Disorders, Lymphoid Malignancies, Study Population, Clinically relevant, Quality Improvement

 

JAMA Oncol; 2021 Jun

Safety and Effectiveness of Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Daratumumab Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma: The MANHATTAN Nonrandomized Clinical Trial

To assess the safety and effectiveness of carfilzomib-lenalidomide-dexamethasone-daratumumab combination therapy for patients with newly diagnosed multiple myeloma, in the absence of high-dose melphalan chemotherapy and autologous hemopoietic cell transplant.

 

J Clin Oncol; 2022 Jun 30

Modern Myeloma Therapy + Sustained Minimal Residual Disease-Negative = (Functional) Cure!

 

Locations

Memorial Sloan-Kettering Cancer Center New York

United States, New Jersey

United States, New York

 

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