What are Multiple myeloma defining events? International Myeloma Working Group - SLiM-CRAB Criteria

Updated: Jun 23, 2022

What are myeloma defining events? The SLiM-CRAB Criteria

International Myeloma Working Group (IMWG) diagnostic criteria for MM

END ORGAN DAMAGE

C = increased calcium levels (greater than 11.5 mg/dL
R = renal insufficiency (creatinine greater than 2 mg/dL or creatinine clearance less than 40 mL/min
A = anemia (hemoglobin less than 10 g/dL or 2 g/dL less than normal
B = presence of bone lesions ( presence of one or more osteolytic lesions seen on skeletal radiography, whole-body MRI, or whole-body FDG PET/CT )

MM DEFINING BIOMARKERS

S = greater than or equal to sixty percent clonal plasma cells in the bone marrow
Li = involved/uninvolved free light chain ratio of 100 or more with the involved FLC being greater than or equal 100 mg/L
M = MRI with more than one focal marrow lesion

Reference:

Updated Diagnostic Criteria and Staging System for Multiple Myeloma - Am Soc Clin Oncol Educ Book; 2016

https://pubmed.ncbi.nlm.nih.gov/27249749/

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