NCT02884102: MMRF Molecular Profiling Protocol - Multiple Myeloma Research Foundation

Updated: Feb 10

MMRF

NCT02884102: MMRF Molecular Profiling Protocol

Multiple Myeloma Research Foundation

Sponsor: Multiple Myeloma Research Foundation

Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative analysis between multiple myeloma or related plasma cell malignancies and normal cells coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of the genetic alterations for the purpose of identifying informative and/or actionable mutations in patients with multiple myeloma and plasma cell malignancies. The approach will enable the detection of point mutations, insertions/deletions, gene fusions and rearrangements, amplifications/deletions, and outlier expressed genes among other classes of alterations.

Genetic: genetic sequencing

Multiple Locations

ClinicalTrials.gov Identifier: NCT02884102

Official Title: Clinical-grade Molecular Profiling of Patients With Multiple Myeloma and Related Plasma Cell Malignancies

First Posted : August 30, 2016

https://clinicaltrials.gov/ct2/show/NCT02884102

NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)

NCT03732703: Phase 1/2: Myeloma-Developing Regimens Using Genomics (MyDRUG)

The Multiple Myeloma Research Consortium® (MMRC®)

What is the MMRC®?

https://themmrf.org/finding-a-cure/our-work/mmrc/

What is the MyDRUG study?