NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Cancer
Updated: Feb 10
RRMM
Relapsed Refractory Multiple Myeloma
NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications
NCT02649790: Phase 1/2: Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications
This is a first-in-human, multi-center, open-label clinical study with separate dose escalation (Phase 1) and expansion (Phase 2) stages to assess preliminary safety, tolerability, and efficacy of the second generation oral XPO1 inhibitor KPT-8602 in participants with relapsed/refractory multiple myeloma (MM), metastatic colorectal cancer (mCRC), metastatic castration resistant prostate cancer (mCRPC), higher risk myelodysplastic syndrome (HRMDS), acute myeloid leukemia (AML) and newly diagnosed intermediate/high-risk MDS.
Sponsor
ClinicalTrials.gov Identifier: NCT02649790
Official Title:A Phase 1/2 Open-Label Study of the Safety, Tolerability and Efficacy of the Selective Inhibitor of Nuclear Export (SINE) Compound Eltanexor (KPT-8602) in Patients With Newly Diagnosed and Relapsed/Refractory Cancer Indications
First Posted : January 7, 2016
Click here to see details on ClinicalTrials.gov
Eltanexor (Code C125193)
(2E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)prop-2-enamide
ATG 016
ATG-016
ATG016
Eltanexor
ELTANEXOR
Exportin 1 Inhibitor KPT-8602
KPT-8602
Selective Inhibitor of Nuclear Export KPT-8602
XPO1-inhibiting SINE Compound KPT-8602
Decitabine and Cedazuridine (Code C115102)
ASTX727
C-DEC
CDA Inhibitor E7727/Decitabine Combination Agent ASTX727
Cedazuridine/Decitabine Combination Agent ASTX727
Cedazuridine/Decitabine Tablet
DEC-C
Decitabine and Cedazuridine
Inqovi
Drug: KPT-8602
Drug: ASTX727
Drug: Dexamethasone
Locations
United States, California
United States, Colorado
United States, Florida
United States, Michigan
United States, Missouri
United States, Nebraska
United States, New Jersey
United States, New Mexico
United States, New York
United States, Ohio
United States, Pennsylvania
United States, Tennessee
United States, Texas
United States, Utah
United States, Virginia
United States, Washington
Canada, Ontario
Canada, Quebec
China, Tianjin
Europe
Spain
France