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Recruiting

NCT04268498: Phase2 - Daratumumab, Carfilzomib, Lenalidomide, Dex NDMM Multiple Myeloma (ADVANCE)

Updated: Feb 21

  • The ADVANCE trial

  • Dara-KRd

  • KRd

  • VRd


ADVANCE MYELOMA TRIAL dara-krd UNIVERSITY MIAMI

NCT04268498: A Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma (ADVANCE)


This study is being done to find out whether carfilzomib, lenalidomide, and dexamethasone (KRD) or KRD and Daratumumab (KRD+DARA) might be safer and more effective ways of controlling multiple myeloma than the standard of care treatment, which is lenalidomide, bortezomib, and dexamethasone (VRD).


Sponsor


Collaborator


Multiple locations

International Study

 

ClinicalTrials.gov Identifier: NCT04268498

Official Title: Phase 2, Open-Label Randomized Study of Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone vs Carfilzomib, Lenalidomide, and Dexamethasone vs Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly-Diagnosed Multiple Myeloma

First Posted: February 13, 2020

Click here for details on ClinicalTrials.gov

 


 

Drug: Bortezomib (Velcade)

Drug: Dexamethasone (Decadron)

Drug: Lenalidomide (Revlimid)

Drug: Acetaminophen

Drug: Diphenhydramine

Drug: Montelukast

Drug: Carfilzomib (Kyprolis)

Drug: Daratumumab (Darzalex)

Biological: Autologous Stem Cell Transplant (ASCT)

 
 

- Florida: Sylvester Comprehensive Cancer Center - University of Miami

- Florida: Moffitt Cancer Center Tampa

- Illinois: Rush University Medical Center Chicago

- New York: Roswell Park Cancer Institute Buffalo

- New York: Memorial Sloan-Kettering Cancer Center New York

- Texas: The University of Texas MD Anderson Cancer Center Houston

 

Locations

United States, Florida

United States, Illinois

United States, New York

United States, Texas

United States, Utah

Sweden

 

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