NCT04394650: Phase 1 - CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in RRMM
CC-98633 CART
NCT04394650: Phase 1 - A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma
This is a Phase 1, multicenter, open-label study of CC-98633, BCMA-Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in subjects with relapsed and/or refractory multiple myeloma.
The study will consist of 2 parts: dose-escalation (Part A) and dose-expansion (Part B). The dose-escalation part (Part A) of the study is to evaluate the safety and tolerability of increasing dose levels of CC-98633 to establish a recommended Phase 2 dose (RP2D); and the dose-expansion part (Part B) of the study is to further evaluate the safety, pharmacokinetics/pharmacodynamics, and efficacy of CC-98633 at the RP2D.
Sponsor
Juno Therapeutics, a Subsidiary of Celgene
ClinicalTrials.gov Identifier: NCT04394650
A Phase I, Multi Center, Open Label Study of CC-98633, BCMA Targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma
First Posted : May 19, 2020
Click here for details on ClinicalTrials.gov
Autologous BCMA-targeted CAR T Cells CC-98633 (Code C173699)
Autologous BCMA-targeted CAR T Cells CC-98633
Autologous BCMA-targeted CAR T-cells CC-98633
Autologous BCMA-targeted NEX-T CAR T Cells CC-98633
CC 98633
CC-98633
CC98633
CART
Biological: CC-98633
Autologous BCMA-targeted CAR T Cells CC-98633
- Multiple locations
- Alabama: University of Alabama at Birmingham
- California: Stanford Cancer Center
- New York: Roswell Park Cancer Institute Buffalo
- New York: Tisch Cancer Institute Mount Sinai Hospital New York
- New York: Memorial Sloan-Kettering Cancer Center New York
- Arizona: Mayo Clinic Arizona
- Illinois: University of Chicago
- Minnesota: Mayo Clinic Rochester Minnesota
- North Carolina: Levine Cancer Institute Charlotte
- Texas: UT Southwestern Medical Center Dallas
Locations
United States, Alabama
United States, Arizona
United States, California
United States, Illinois
United States, Kansas
United States, Minnesota
United States, New York
United States, North Carolina
United States, Texas