NCT01080391: Comparing Carfilzomib, Lenalidomide & Dex (CRd) vs Lenalidomide and Dex (Rd) - ASPIRE
Updated: Jun 13, 2022
THE ASPIRE TRIAL
Phase 3 Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
KRd Vs Rd
The primary objective was to compare progression-free survival in adults with relapsed multiple myeloma who are receiving CRd vs participants receiving Rd in a randomized multicenter setting.
Phase 3 Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
Sponsor
Amgen
Multiple Locations
International Study
ClinicalTrials.gov Identifier: NCT01080391
Official Title: A Randomized, Multicenter, Phase 3 Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects With Relapsed Multiple Myeloma
First Posted : March 4, 2010
Click here for details on ClinicalTrials.gov
Publications:
Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma.
N Engl J Med. 2015 Jan 8
Carfilzomib in relapsed or refractory multiple myeloma patients with early or late relapse following prior therapy: A subgroup analysis of the randomized phase 3 ASPIRE and ENDEAVOR trials
Hematol Oncol. 2018 Apr
Health-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.
J Clin Oncol. 2016 Nov 10
Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment -
This subgroup analysis of ASPIRE evaluated KRd vs Rd by number of previous lines of therapy and previous exposure to bortezomib, thalidomide or lenalidomide
Blood Cancer J;2017 Apr 21
- Arizona: Mayo Clinic Arizona
- Colorado: Sarah Cannon/Colorado Blood Cancer Institute Denver
- Illinois: Rush University Medical Center Chicago
- Minnesota: Mayo Clinic Rochester Minnesota
- New York: New York Presbyterian / Weill Cornell Medical College New York
- New York: NYU Langone Medical Center New York
- Texas: The University of Texas MD Anderson Cancer Center Houston
- Texas: UT Southwestern Medical Center Dallas
- Texas: Baylor University Medical Center Dallas
- Wisconsin: Froedtert Memorial Milwaukee
Locations
United States, Arizona
United States, California
United States, Colorado
United States, Florida
United States, Illinois
United States, Indiana
United States, Kansas
United States, Michigan
United States, Minnesota
United States, New Jersey
United States, New York
United States, Tennessee
United States, Texas
United States, Washington
United States, Wisconsin
Canada, Alberta
Canada, British Columbia
Canada, Manitoba
Canada, Newfoundland and Labrador
Canada, Ontario
Canada, Quebec
Europe
United Kingdom
Austria
Belgium
Bulgaria
Czechia
France
Germany
Greece
Hungary
Italy
Netherlands
Poland
Romania
Serbia
Spain
Sweden
Asia
Russian Federation
Israel