NCT03289299 : Phase 2 - Agg. Smoldering Curative Approach Eval. Novel Therapies & Transplant ASCENT
Updated: May 23, 2022
ASCENT TRIAL
Dara-KRd
Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant (ASCENT)
This study evaluates the use of carfilzomib, lenalidomide, daratumumab, and dexamethasone in subjects with high-risk smoldering multiple myeloma (SMM). Subjects will receive treatment in 3 phases - induction (6 cycles), consolidation (6 cycles), and maintenance (12 cycles). Each cycle is 28 days.
Aggressive Smoldering Curative Approach Evaluating Novel Therapies and Transplant (ASCENT)
Sponsor
International Myeloma Foundation
Collaborators
Amgen
Janssen Scientific Affairs, LLC
Celgene
Trevie, Inc.
ClinicalTrials.gov Identifier: NCT03289299
Official Title: Aggressive Smoldering Curative Approach Evaluating Novel Therapies (ASCENT): A Phase 2 Trial of Induction, Consolidation, and Maintenance in Subjects With High Risk Smoldering Multiple Myeloma (SMM)
First Posted : September 20, 2017
Click here for details on ClinicalTrials.gov
Aggressive Smoldering Curative Approach Evaluating Novel Therapies (ASCENT): A Phase 2 Trial of Induction, Consolidation and Maintenance in Subjects with High Risk Smoldering Multiple Myeloma (SMM): Initial Analysis of Safety Data
Online Publications; Scientific Abstracts
62nd ASH Annual meeting
653.Myeloma/Amyloidosis: Therapy, excluding Transplantation
November 5, 2020
Drug: Carfilzomib
Drug: Lenalidomide
Drug: Daratumumab
Drug: Dexamethasone
-Multiple locations
- Illinois: University of Chicago
- Florida: Moffitt Cancer Center Tampa
- Minnesota: Mayo Clinic Rochester Minnesota
- North Carolina: Levine Cancer Institute Charlotte
- New York: New York Presbyterian / Weill Cornell Medical College New York
- Wisconsin: Medical College Of Wisconsin Milwaukee
Locations
United States, Florida
United States, Illinois
United States, Indiana
United States, Kansas
United States, Maryland
United States, Minnesota
United States, New York
United States, North Carolina
United States, Washington
United States, Wisconsin